Growth Factor Concentrate (GFC) for the Management of Osteoarthritis of the Knee: A Systematic Review (2024)

1 July 2024

Indian J Orthop. 2024 May 9;58(7):829-834. doi: 10.1007/s43465-024-01172-w. eCollection 2024 Jul.

ABSTRACT

INTRODUCTION: The knee is the most commonly affected joint in osteoarthritis (OA), affecting millions of people worldwide. Knee OA significantly impacts the activities of daily living (ADL) along with affecting overall quality of life of patients (QoL), thereby leading to substantial socio-economic burden. Conservative therapies are prioritized, resorting to surgery only when needed. However, these traditional approaches have limitations. Regenerative medicine, involving the use of orthobiologics, including autologous peripheral blood-derived orthobiologics such as growth factor concentrate (GFC), has evolved and shown potential for managing knee OA. The primary goal of this review is to summarize the results of in vitro, preclinical and clinical studies involving GFC for the management of knee OA.

METHODS: Multiple databases (PubMed, Scopus, Google Scholar, Web of Science and Embase) were searched applying terms for the intervention ‘GFC’ and treatment ‘knee OA’ for the studies published in the English language to March 10, 2024.

RESULTS: Only three clinical studies met our pre-defined criteria and were included in this review.

CONCLUSION: Intra-articular administration of GFC is safe and potentially efficacious to manage OA of the knee. More, adequately powered, multi-center, prospective, RCTs are warranted to demonstrate the long-term effectiveness of GFC in patients suffering from mild-to-moderate knee OA and to justify its routine clinical use. Further studies evaluating the efficacy of GFC compared to other orthobiologics are also required to allow physicians/surgeons to choose the optimal orthobiologic for the treatment of OA of the knee.

PMID:38948375 | PMC:PMC11208381 | DOI:10.1007/s43465-024-01172-w

Document this CPDCopy URL Button

LinkedIn Share

Estimated reading time: 5 minute(s)

Growth Factor Concentrate (GFC) for the Management of Osteoarthritis of the Knee: A Systematic Review (7)

Copy WordPress Title
  • Effect of local mud application in patients with knee osteoarthritis - A systematic review and meta-analysis
  • Automated system for classifying uni-bicompartmental knee osteoarthritis by using redefined residual learning with convolutional neural network
  • The effect of intra-articular ozone injection combined with home-based exercise on pain and function in daily living activities of patients with mild to moderate knee osteoarthritis, a randomized double-blinded controlled clinical trial
  • Capability After Total Knee Arthroplasty for Osteoarthritis Is Strongly Associated With Preoperative Symptoms of Depression
  • Capability After Total Knee Arthroplasty for Osteoarthritis Is Strongly Associated With Preoperative Symptoms of Depression
  • Total knee replacement in different age groups
  • Usability and preliminary effectiveness of an app-based physical activity and education program for people with hip or knee osteoarthritis - a pilot randomized controlled trial
  • Heat and Acupuncture to Manage Osteoarthritis of the Knee (HARMOKnee): Protocol for an Effectiveness-Implementation Hybrid Randomized Controlled Trial
  • Resilience as a psychiatric factor affecting outcomes after total joint arthroplasty: a systematic review
  • Evaluation of the consistency of the MRI- based AI segmentation cartilage model using the natural tibial plateau cartilage
  • Risk factors for failure of manipulation under anesthesia after total knee arthroplasty
  • Gaining Insight into Updated MR Imaging for Quantitative Assessment of Cartilage Injury in Knee Osteoarthritis
  • Reconstruction of 3D knee MRI using deep learning and compressed sensing: a validation study on healthy volunteers
  • Prediction of specific structural damage to the knee joint using qualitative isokinetic analysis
  • Navigating the Divide: A Comprehensive Review of the Mechanical and Anatomical Axis Approaches in Total Knee Replacement
  • The efficacy and safety of perioperative glucocorticoid for total knee arthroplasty: a systematic review and meta-analysis
  • Association Between Statin Use and the Incidence of Clinically Diagnosed Osteoarthritis: A Nationwide Retrospective Cohort Study in Taiwan
  • Orthopedic Conditions and Interplay with Functional Abilities and MECP2 Variant Subtype in Rett Syndrome Patients
  • Anxiety and depression prior to total knee arthroplasty are associated with worse pain and subjective function: A prospective comparative study
  • IMPACT OF THE COVID-19 PANDEMIC ON ELECTIVE KNEE SURGERIES IN ATHLETES
  • Exploration beyond osteoarthritis: the association and mechanism of its related comorbidities
  • Knee Buckling as an Atypical Adverse Effect of Clozapine: A Case Report
  • Increased Risk of Postoperative Complications in Patients Who Have Obstructive Sleep Apnea Undergoing Total Joint Arthroplasty: A Systematic Review and Meta-Analysis
  • Trend of using cementless total knee arthroplasty: a nationwide analysis from 2015 to 2021
  • Inverse kinematic total knee arthroplasty using conventional instrumentation restores constitutional coronal alignment
  • Visual interpretable MRI fine grading of meniscus injury for intelligent assisted diagnosis and treatment
  • Automated quantitative assessment of bone contusions and overlying articular cartilage following anterior cruciate ligament injury
  • Automated quantitative assessment of bone contusions and overlying articular cartilage following anterior cruciate ligament injury
  • Alzheimer Disease-Link With Major Depressive Disorder and Efficacy of Antidepressants in Modifying its Trajectory
  • Health-related quality of life and related factors in patients with colorectal cancer in Iran: a systematic review
  • Health-related quality of life and related factors in patients with colorectal cancer in Iran: a systematic review
  • The Role of Platelet Rich Plasma in Vertebrogenic and Discogenic Pain: A Systematic Review and Meta-Analysis
  • Pro- and anti-inflammatory cytokines are the game-changers in childhood obesity-associated metabolic disorders (diabetes and non-alcoholic fatty liver diseases)
  • Understanding the influence of different proxy perspectives in explaining the difference between self-rated and proxy-rated quality of life in people living with dementia: a systematic literature review and meta-analysis
  • Assessing intrinsic capacity in Taiwan: Initial psychometric properties of the Integrated Care for Older People Screening Tool for Taiwanese (ICOPES-TW)
  • Bilateral juvenile osteochondrosis dissecans in monozygotic twins: a case report
  • Evaluating the accuracy and relevance of ChatGPT responses to frequently asked questions regarding total knee replacement
  • Digital biomarkers: 3PM approach revolutionizing chronic disease management - EPMA 2024 position
  • Andexanet Alfa versus Four-Factor Prothrombin Complex Concentrate for the Reversal of Factor Xa (FXa) Inhibitor-Associated Intracranial Hemorrhage: A Systematic Review of Retrospective Studies
  • David Scott: Prevention of future deaths report
  • Depression and associated factors among older people in Vietnam: Findings from a National Aging Survey
  • Postoperative pain score does not correlate with injury severity in isolated tibial plateau fractures
  • Postoperative pain score does not correlate with injury severity in isolated tibial plateau fractures
  • Factors associated with the Single Leg Squat test in female soccer players: a cross-sectional study
  • TNF receptor 2 knockout mouse had reduced lung cancer growth and schizophrenia-like behavior through a decrease in TrkB-dependent BDNF level
  • An update on clinical gait analysis : Current developments and applications
  • Trim14-IkBa signaling regulates chronic inflammatory pain in rats and osteoarthritis patients
  • Investigating the role of TGF-β and BDNF in cancer-related depression: a primary cross-sectional study
  • Palliative care considerations for the older adults with HIV/AIDS: a clinical practice review
  • Quality of life in a high-risk group of elderly primary care patients: characteristics and potential for improvement
  • Use of natural language processing techniques to predict patient selection for total hip and knee arthroplasty from radiology reports
  • The Evolving Landscape of Cervical Cancer: Breakthroughs in Screening and Therapy Through Integrating Biotechnology and Artificial Intelligence
  • Efficacy and Safety of Fibroblast Growth Factor-21 Analogs for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis: A Systematic Review and Meta-Analysis
  • Combined nutritional status and activities of daily living disability is associated with one-year mortality after hip fracture surgery for geriatric patients: a retrospective cohort study
  • The Synergistic Impact of Probiotics and Dietary Fiber on Constipation Management in Chlorpromazine-Induced Schizophrenia Patients: Exploring the Modulation of Intestinal Microbiota and Neurotrophic Factors
  • Efficacy of rTMS combined with cognitive training in TBI with cognition disorder: a systematic review and meta-analysis
  • A Novel Deep Learning Approach for Forecasting Myocardial Infarction Occurrences with Time Series Patient Data
  • Opportunities to optimise care and choice in joint replacement surgery using a digitally delivered, holistic PreHab pathway
  • Current Findings and Potential Mechanisms of KarXT (Xanomeline-Trospium) in Schizophrenia Treatment
  • Enhancing nerve regeneration in infraorbital nerve injury rat model: effects of vitamin B complex and photobiomodulation
  • Validating a Novel 2D to 3D Knee Reconstruction Method on Preoperative Total Knee Arthroplasty Patient Anatomies
  • Recent advances in lung cancer research: unravelling the future of treatment
  • Unveiling the Role of Artificial Intelligence (AI) in Polycystic Ovary Syndrome (PCOS) Diagnosis: A Comprehensive Review
  • Investigating resistance to antidepressants in animal models

Growth Factor Concentrate (GFC) for the Management of Osteoarthritis of the Knee: A Systematic Review (74)

(recent articles with at least 5 words in title)

Floating Tab

CME/CPD

  • Does playing football really increase the risk of knee osteoarthritis? A Systematic Review and Meta-analysis
  • Effect of local mud application in patients with knee osteoarthritis - A systematic review and meta-analysis
  • Automated system for classifying uni-bicompartmental knee osteoarthritis by using redefined residual learning with convolutional neural network
  • The effect of intra-articular ozone injection combined with home-based exercise on pain and function in daily living activities of patients with mild to moderate knee osteoarthritis, a randomized double-blinded controlled clinical trial
  • Research Progress on the Pathogenesis of Knee Osteoarthritis
  • Alcoholic drink produced by pea is a risk factor for incident knee surgery in patients with knee osteoarthritis
  • Capability After Total Knee Arthroplasty for Osteoarthritis Is Strongly Associated With Preoperative Symptoms of Depression
  • Capability After Total Knee Arthroplasty for Osteoarthritis Is Strongly Associated With Preoperative Symptoms of Depression
  • Machine learning and deep neural network-based learning in osteoarthritis knee
  • Total knee replacement in different age groups
  • Disease progression and clinical outcomes in latent osteoarthritis phenotypes: Data from the Osteoarthritis Initiative
  • Physical and psychosocial characteristics differ between individuals with knee pain and different knee osteoarthritis diagnostic criteria
  • Deep learning based phenotyping of medical images improves power for gene discovery of complex disease
  • 2-Dimensional and 3-Dimensional MR Imaging-Aid to Knee Preservation Surgery: Focus on Meniscus and Articular Cartilage
  • Cruciate and Collateral Ligaments: 2-Dimensional and 3-Dimensional MR Imaging-Aid to Knee Preservation Surgery
  • Alignment strategy for different types of varus knee with generic instruments: Mechanical alignment or kinematic alignment?
  • Subcortical brain anatomy as a potential biomarker of persistent pain after total knee replacement in osteoarthritis
  • Usability and preliminary effectiveness of an app-based physical activity and education program for people with hip or knee osteoarthritis - a pilot randomized controlled trial
  • Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021
  • Heat and Acupuncture to Manage Osteoarthritis of the Knee (HARMOKnee): Protocol for an Effectiveness-Implementation Hybrid Randomized Controlled Trial
  • Quantitative sensory testing, psychological factors, and quality of life as predictors of current and future pain in patients with knee osteoarthritis
  • Quantitative sensory testing, psychological factors, and quality of life as predictors of current and future pain in patients with knee osteoarthritis
  • Socioeconomic inequalities in patient-reported outcome measures of Dutch primary hip and knee arthroplasty patients for osteoarthritis
  • Psychosocial Determinants of Knee Osteoarthritis Progression: Results from the Promoting Independence in Our Seniors with Arthritis (PISA) Study
  • TissueGene-C induces long-term analgesic effects through regulation of pain mediators and neuronal sensitization in a rat monoiodoacetate-induced model of osteoarthritis pain
  • Does Running Increase the Risk of Hip and Knee Arthritis? A Survey of 3804 Marathon Runners
  • Predicting whether patients will achieve minimal clinically important differences following hip or knee arthroplasty
  • Bidirectional causal relationship between psychiatric disorders and osteoarthritis: A univariate and multivariate Mendelian randomization study
  • Resilience as a psychiatric factor affecting outcomes after total joint arthroplasty: a systematic review
  • Evaluation of the consistency of the MRI- based AI segmentation cartilage model using the natural tibial plateau cartilage
  • Effects of preoperative anxiety level on pain level and joint functions after total knee arthroplasty
  • Characteristics and influencing factors of early pain in patients after total knee arthroplasty
  • Neuropathic pain in patients with primary knee osteoarthritis: A cross-sectional study
  • Risk factors for failure of manipulation under anesthesia after total knee arthroplasty
  • Gaining Insight into Updated MR Imaging for Quantitative Assessment of Cartilage Injury in Knee Osteoarthritis
  • CORR Insights: What Are the Underlying Mental Health Constructs Associated With Level of Capability in People With Knee and Hip Osteoarthritis?
  • Effects of Inspiratory Muscle Training in Patients With Pulmonary Hypertension
  • Reconstruction of 3D knee MRI using deep learning and compressed sensing: a validation study on healthy volunteers
  • Causal relationship between diet and knee osteoarthritis: A Mendelian randomization analysis
  • Factors associated with pressure pain threshold in both local and remote sites in knee osteoarthritis
  • Prediction of specific structural damage to the knee joint using qualitative isokinetic analysis
  • Navigating the Divide: A Comprehensive Review of the Mechanical and Anatomical Axis Approaches in Total Knee Replacement
  • Reliability and validity of the Japanese short-form arthritis self-efficacy scale in patients with knee osteoarthritis: A cross-sectional study
  • Mental Health Effects on the Minimal Clinically Important Difference in Total Joint Arthroplasty
  • Correction: Accelerated Care of Patients with Hip Fractures is Associated with Lower Risk of Delirium and Infection, and a Shorter Length of Hospital Stay: Systematic Review and Meta-analysis of Level One Evidence
  • The efficacy and safety of perioperative glucocorticoid for total knee arthroplasty: a systematic review and meta-analysis
  • Association Between Statin Use and the Incidence of Clinically Diagnosed Osteoarthritis: A Nationwide Retrospective Cohort Study in Taiwan
  • The effectiveness of virtual reality, augmented reality and mixed reality rehabilitation in total knee arthroplasty: a systematic review and meta-analysis
  • Orthopedic Conditions and Interplay with Functional Abilities and MECP2 Variant Subtype in Rett Syndrome Patients
  • Analysis of robot-specific operative time and surgical team anxiety level and its effect on alignment during robot-assisted TKA
  • Analysis of robot-specific operative time and surgical team anxiety level and its effect on alignment during robot-assisted TKA
  • Effect of virtual reality hypnosis on intraoperative sedation needs and functional recovery in knee arthroplasty: a prospective randomized clinical trial
  • Anxiety and depression prior to total knee arthroplasty are associated with worse pain and subjective function: A prospective comparative study
  • IMPACT OF THE COVID-19 PANDEMIC ON ELECTIVE KNEE SURGERIES IN ATHLETES
  • Feasibility of pain informed movement program for people with knee osteoarthritis
  • Pain Informed Movement for people with knee osteoarthritis: Protocol for a pilot randomized controlled trial
  • Association of ABCB1 gene polymorphisms rs1128503, rs2032582, rs4148738 with anemia in patients receiving dabigatran after total knee arthroplasty
  • Intracluster correlation coefficients in osteoarthritis cluster randomized trials: a systematic review
  • Treating Sleep Disorders After Total Hip and Total Knee Arthroplasty
  • Development of an automated optimal distance feature-based decision system for diagnosing knee osteoarthritis using segmented X-ray images
  • Exploration beyond osteoarthritis: the association and mechanism of its related comorbidities
  • "Adjacent Bed Effect" of Total Knee Arthroplasty Patients During the Perioperative Period
  • Effects of a Virtual Reality Cycling Platform on Lower Limb Rehabilitation in Patients With Ataxia and Hemiparesis: Pilot Randomized Controlled Trial
  • Exploring the pain and disability continuum in adolescents with non-traumatic anterior knee pain: a mediation analysis using individual participant data of prospective studies

Inpsychology

New Evidence

1 July 2024

Social interactions offset the detrimental effects of digital media use on children’s vocabulary

Front Dev Psychol. 2024;2:1401736. doi: 10.3389/fdpys.2024.1401736. Epub 2024 May 27.ABSTRACTYoung children's rapid vocabulary growth during the first few years is supported by input during social...

1 July 2024

Growing pains with kratom: experiences discussed in subreddits contrast with satisfaction expressed in surveys

Front Pharmacol. 2024 Jun 14;15:1412397. doi: 10.3389/fphar.2024.1412397. eCollection 2024.ABSTRACTBACKGROUND: "Kratom" refers to an array of bioactive products derived from Mitragyna speciosa, a tree indigenous to...

1 July 2024

Cultivating Comfort: Examining Participant Satisfaction with Hypnotic Communication Training in Pain Management

J Multidiscip Healthc. 2024 Jun 24;17:2973-2987. doi: 10.2147/JMDH.S463738. eCollection 2024.ABSTRACTCONTEXT: One in four Canadians experiences chronic pain, yet insufficient services and restrictions surrounding prevailing treatments...

1 July 2024

Social interactions offset the detrimental effects of digital media use on children’s vocabulary

Front Dev Psychol. 2024;2:1401736. doi: 10.3389/fdpys.2024.1401736. Epub 2024 May 27.ABSTRACTYoung children's rapid vocabulary growth during the first few years is supported by input during social...

1 July 2024

Growing pains with kratom: experiences discussed in subreddits contrast with satisfaction expressed in surveys

Front Pharmacol. 2024 Jun 14;15:1412397. doi: 10.3389/fphar.2024.1412397. eCollection 2024.ABSTRACTBACKGROUND: "Kratom" refers to an array of bioactive products derived from Mitragyna speciosa, a tree indigenous to...

1 July 2024

Cultivating Comfort: Examining Participant Satisfaction with Hypnotic Communication Training in Pain Management

J Multidiscip Healthc. 2024 Jun 24;17:2973-2987. doi: 10.2147/JMDH.S463738. eCollection 2024.ABSTRACTCONTEXT: One in four Canadians experiences chronic pain, yet insufficient services and restrictions surrounding prevailing treatments...

Growth Factor Concentrate (GFC) for the Management of Osteoarthritis of the Knee: A Systematic Review (2024)

References

Top Articles
Latest Posts
Article information

Author: Frankie Dare

Last Updated:

Views: 5622

Rating: 4.2 / 5 (53 voted)

Reviews: 92% of readers found this page helpful

Author information

Name: Frankie Dare

Birthday: 2000-01-27

Address: Suite 313 45115 Caridad Freeway, Port Barabaraville, MS 66713

Phone: +3769542039359

Job: Sales Manager

Hobby: Baton twirling, Stand-up comedy, Leather crafting, Rugby, tabletop games, Jigsaw puzzles, Air sports

Introduction: My name is Frankie Dare, I am a funny, beautiful, proud, fair, pleasant, cheerful, enthusiastic person who loves writing and wants to share my knowledge and understanding with you.